Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Follow your doctor's instructions about any restrictions on food, beverages, or activity. If you also take cyclosporine, take the sirolimus at least 4 hours after taking cyclosporine.
Endometriosis patients - You must take danazol consistently for 3 to 6 months. It may be necessary to take danazol for 9 months. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Serious and sometimes fatal blood clots eg, stroke increased pressure in the head, and liver problems have been reported with the use of danazol. Notify your doctor immediately if you develop any of the following: calf or leg pain, redness, tenderness, or swelling; chest pain; fainting; headache; nausea or vomiting; shortness of breath; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; vision changes.
What is the most important information I should know about danazol Danocrine? Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. Danocrine can induce ALA synthetase activity and hence porphyrin metabolism. Thromboembolism, thrombotic and thrombophlebitic events including sagittal sinus thrombosis and life-threatening or fatal strokes have been reported. Danazol is usually given for 6 to 9 months to treat fibrocystic breast disease or endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term. Follow your doctor's instructions.
Using this medicine may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking this medicine, check with your doctor right away. Other side effects in female patients have included virilization, including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities, due the androgenic activity of danazol the active ingredient contained in Danocrine Discontinuation of danazol at signs of mild virilization may prevent irreversible virilization. Reduction in breast size may occur due to decreased estrogen synthesis.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Seifer DB, Freedman LN, Cavender JR, Baker RA "Insulin-dependent diabetes mellitus associated with danazol. Danazol treatment may interfere with laboratory determinations of testosterone, androstenedione and dehydroepiandrosterone. Other metabolic events include a reduction in thyroid binding globulin and T4 with increased uptake of T3, but without disturbance of thyroid stimulating hormone or of free thyroxin index. The dosage is based on your medical condition and response to treatment. Our Danocrine danazol Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. It is very important that your doctor check your progress at regular visits to make sure that this medicine does not cause unwanted effects. Blood tests may be needed to check for unwanted effects. Gastrointestinal side effects have included nausea and vomiting. Rare cases of pancreatitis have been reported.
Sirolimus may cause a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Use a barrier method of birth control, such as a condom or diaphragm, while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. Store at room temperature away from moisture and heat. Your pharmacist can provide more information about sirolimus.
Where can I get more information? Take danazol by mouth with or without food. Sirolimus is usually taken once a day. If you also take cyclosporine, wait at least 4 hours after your cyclosporine dose before you take sirolimus. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Middleton C, McCaughan GW, Painter DM, Stephen MS, Beale M, Fraser I "Danazol and hepatic neoplasia: a case report. Do not use danazol if you are pregnant. It may cause serious harm to a fetus. It is recommended that a pregnancy test be performed before starting danazol. Effective, nonhormonal birth control measures, such as diaphragms and condoms, should be used while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. If you become pregnant while taking danazol, stop use and contact your doctor right away.
Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. MACE in association with use of testosterone replacement therapy in men. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Makdisi WJ, Cherian R, Vanveldhuizen PJ, Talley RL, Stark SP, Dixon AY "Fatal peliosis of the liver and spleen in a patient with agnogenic myeloid metaplasia treated with danazol. Following an initial favorable response prevention of edematous episodes attempts should be made at 1 to 3 month intervals to reduce the dosage to the minimum continuous dose that will prevent angioedema. Dosage reductions up to 50% per interval may be considered. Should angioedema recur, the daily dosage may be increased up to 200 mg. What other drugs will affect danazol? Undiagnosed abnormal genital bleeding. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. National Library of Medicine and Drugs. This information is generalized and not intended as specific medical advice. Before initiating therapy of fibrocystic breast disease with Danazol, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Danazol may raise the plasma levels of cyclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs. Monitoring of systemic concentrations of these drugs and appropriate dose adjustments may be needed when used concomitantly with Danazol. Kahn H, Manzarbeitia C, Theise N, et al "Danazol-induced hepatocellular adenomas: A case report and review of the literature. In the treatment of endometriosis, Danazol alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Williams G "Metabolic effects of danazol. DANOCRINE, persistent amenorrhea has occasionally been reported. Do not use any other liquids to mix this medicine. If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation. Kingsbury AC "Danazol and fetal masculinization: a warning.
Resolution of pain and tenderness usually occurs following 1 to 3 months of therapy. Elimination of nodules often requires 4 to 6 months of uninterrupted therapy. Symptoms recur within one year in 50% of patients and therapy may be reinitiated if necessary. Fraser IS "Post danazol amenorrhoea. Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. What should I discuss with my doctor before taking sirolimus Rapamune? Hepatic side effects have included life-threatening peliosis hepatitis and benign hepatic adenoma following prolonged danazol the active ingredient contained in Danocrine administration. Rare cases of hepatic neoplasms following prolonged use have been reported. Danazol can exacerbate acute intermittent porphyria. Serum transaminase levels may be increased. Do not keep outdated medicine or medicine no longer needed. Gray RG "Bilateral carpal tunnel syndrome and arthritis associated with Danazol administration. Tell your doctor or dentist that you take danazol before you receive any medical or dental care, emergency care, or surgery. LOT of weight, my voice lowered, and I grew hair like crazy on my face. It's nearly 25 years later, and I still have a low voice, dark thick hair that grows all over my face, and I'm still struggling with my weight. I'm also convinced this medication had an effect on my ears, as I've had problems with vertigo since taking Danocrine. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes eg mood swings, nervousness; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; unusual bleeding or bruising; vision problems; vomiting. Take the sirolimus tablet with a full glass of water. Barbieri RL "Danazol and thyroid function.
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Your doctor may occasionally change your dose to make sure you get the best results. Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using danazol.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Tell your doctor all medications and supplements you use. What are the possible side effects of danazol Danocrine? Danazol is an androgen similar to testosterone. For the treatment of endometriosis and fibrocystic breast disease, it works by decreasing the amount of hormones made by the ovaries. These hormones usually make the conditions worse. For the treatment of angioedema, danazol helps to increase the amount of a certain protein in your body's defense system immune system.
Do not use Danocrine if you are pregnant. Tell your doctor if you become pregnant during treatment. Before you start taking Danocrine, you may need to have a to make sure you are not pregnant. Use an effective barrier form of birth control such as a condom or with spermicide gel or inserts. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective to prevent pregnancy during treatment. Breastfeeding is not recommended while using this drug. Danazol can increase the calcemic response to alpha calcidol in primary hypoparathyroidism.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Madanes AE, Farber M "Danazol. Abnormalities in laboratory tests may occur during therapy with Danocrine including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins.